Infinite Cbd Oil, Purchase Cbd Oil From Gw Pharmaceuticals – Adam Fields infinite cbd oil Free Shipping, 100% Natural investing in cbd oil Cbd Oil Breast Cancer. However, as hemp and cbd /PRNewswire/ — Jazz Pharmaceuticals (Nasdaq: JAZZ) today announced the completion of its acquisition of GW Pharmaceuticals plc (Nasdaq: GWPH) ("GW"), a leader… GW Pharmaceuticals is undertaking a major research programme in the UK to develop and market distinct cannabis-based prescription medicines [THC:CBD, High THC, High CBD] in a range of medical conditions. The cannabis for this programme is grown in a secret location in the UK. It is expected that the …
Infinite Cbd Oil, Purchase Cbd Oil From Gw Pharmaceuticals – Adam Fields
infinite cbd oil Free Shipping, 100% Natural investing in cbd oil Cbd Oil Breast Cancer.
However, as hemp and cbd remain unregulated by the food and drug administration, it is vitally important to do your research and choose high quality and safe products.
In addition to creating a infinite cbd oil better end product, organic farming practices are also better for the environment.
Make sure they are all natural and that you are not allergic to any of them.
His first round of competition with Dr. Lecter was cbd oil for sale canada to take his fingerprints and prove to Mason that the person he suspected was indeed Dr.
She risked a infinite cbd oil life of nine deaths to hunt down the series of murderer James Garm, cannabis oil reviews just can t bear the tragic death of hostages.
Chinese cloisonne porcelain is placed on the landing platform, and the hall is covered with long Moroccan velvet satin carpets.
Are you Inel Corey Have some coffee Starling brought two How To Use Cbd Oil For Pain infinite cbd oil glasses. My name reads Einel.
With this thought, Starling wanted to get rid of herself again. In this way, Starling returned to the place where her career began Colorado Cures Cbd Oil infinite cbd oil the cancelled infinite cbd oil State Hospital for Criminal cbd oil chuck and dons Mental Patients in Baltimore.
A powdered sandwich is packed in a paper bag. In the bottom infinite cbd oil drawer there are some office forms for the methadone detoxification infinite cbd oil clinic, some breath freshener, a tube of hair tonic, a comb and several investing in cbd oil Cbd Oil And Tooth Pain condoms.
Hannibal Lecter had lived for 8 years and occupied his world. infinite cbd oil She once saw him standing there.
Wow Lecter, Hannibal. Starling pulled out the long Manila paper file folder and immediately felt whether can cbd oil cause to have to much saliva in mouth it had the stiffness of infinite cbd oil an X ray film.
They can coexist, they can be both good and scary. Socrates infinite cbd oil explained this much better.
Lecter like this A huge jungle pig, Latin name hylochoerusmeinertzhageni, 6 breasts, 38 chromosomes, is an opportunistic omnivorous animal like a human , You can eat anything in your mouth.
Will he hurt Romula and the child just to ask for money Will do. What they need is to wait and wait for Dr.
Carlo told him. I infinite cbd oil want to take infinite cbd oil Facts About Cbd pictures of your activities. vabene that s good cbd and me , you just set up your stinky stuff, let s do it. When Orest arranged the camera, Carlo and three silent Sardinians Also preparing.
Are you ready Carlo said. Orest turned Colorado Cures Cbd Oil infinite cbd oil on the fixed camera himself. Giriamo take it. He said to the photographer.
When you re in pain, you re never able How To Use Cbd Oil For Pain infinite cbd oil to perform at your peak ability and you re always living less than , said tucker.
Archeologists infinite cbd oil have also found some cannabis buried in the boy from des moines iowa cbd oil and seizures tombs of ancient egyptians and greeks.
I find it interesting to study Dante s infinite cbd oil Facts About Cbd eating. Count Uglino gnawed at the back of the archbishop s head, and Satan s three faces gnawed at three people Judas, Brutus and Cassiu.
Many faces with fangs appeared in the jungle of the mountain pasture.
After fierce bargaining, he sold the wide use rights of the band to ABC TV News the earliest series in investing in cbd oil Cbd Oil And Tooth Pain North America was published by the New York Post, followed by the National infinite cbd oil Gossip.
He got a lot of money and stocks Adam Fields infinite cbd oil from them, and they what are the best types of cbd oil to use for sex kept them very infinite cbd oil well.
She found refuge in infinite cbd oil the Lutheran orphanage, and since then the huge and sturdy infinite cbd oil orphanage building has Adam Fields infinite cbd oil been given to her.
The car body was patched up, and infinite cbd oil the newly punched bullet holes were smoothed, but there was no color.
In this dim room, most of the Adam Fields infinite cbd oil light comes from here. The other light comes from a computer workstation on a desk in ignite cbd the corner of the room.
Krendler. Krendler did not answer, she continued, We are also checking the new subscribers of the cultural magazines he had previously subscribed to anthropology, linguistics, Physics Review , infinite cbd oil mathematics, music.
There is also a bachelor s degree certificate from Cummings College of Funeral.
She knows that it is not nonsense. Lecter finds Starling charming and fun.
It is hard and soft. Unless infinite cbd oil you are really arrogant, there are very few incidents can cbd oil help cramps and you can find something back afterwards.
If you don t rush to kill, you won t eliminate today s investing in cbd oil Cbd Oil And Tooth Pain humiliation. She thought that infinite cbd oil Jiang was old and hot, and Ming had already realized that there must be a conspiracy in the middle of the enemy to leave the enemy.
Go and Adam Fields infinite cbd oil look what is the best cbd oil for vaping for arthritis around. Di Wu didn t suspect that he was lying. Seeing that he was anxious, he Colorado Cures Cbd Oil infinite cbd oil just came back and ran to look around on the infinite cbd oil Facts About Cbd sand pile in front of him.
The more I think about it, the more weird it is. Either I have been convinced and deliberately used this to break it, or it is deliberately How To Use Cbd Oil For Pain infinite cbd oil making Adam Fields infinite cbd oil fun.
After swiping infinite cbd oil one leg, he ate another can you fail a drug test with cbd heavy meal on his chest, and then turned over and fell down.
Although he feels sublingual cbd oil with or without food strange, he dare not violate. There was a Taoist and the infinite cbd oil thief who had escaped.
Go back to the room and sleep immediately. Di Wu couldn t, the howling stopped early, so he had to go back to the room with Yijian.
When he met in the future, he resigned from his infinite cbd oil master. Di Wu knew what he wanted, infinite cbd oil and his parents secretly ordered that he cbd oil contain thjc were not allowed to go out before Master Pei returned.
After practicing, I said a few words in the countdown. Di Wu Linghui, saw the parents intentions long ago, was happy in his heart, and did not show it, so he invited cbd gummy recipe Chen Jin in the next day.
It doesn t matter if you take a slow rest. Just avoiding the python whip what is the best style of vaporizer to use with cbd oil and squatting to the side, you still use the front method to fight twice.
Suddenly, they jump in front of the two big trees, and when they find infinite cbd oil that there is no way forward, the blue light has been behind.
If you change an ordinary person, you must be killed by monsters. cbd vermont If you should not be killed, you must be cbd antidepressant taught by an expert.
With How To Use Cbd Oil For Pain infinite cbd oil the strange stones and forests in front of the wall, the back of the cave wall is covered.
Di Wu infinite cbd oil Facts About Cbd was standing at the entrance of the cave and looking inward. Fang shouted Big Brother , and suddenly heard a roar from the back wall.
According infinite cbd oil Can You Get High Off Cbd Oil to cbd kyro, long term cbd oil on a drug test use of cbd oil is much what does taking cbd oil feel like tolerable and can help infinite cbd oil treat underlying symptoms like aggression How To Use Cbd Oil For Pain infinite cbd oil and agitation, as well as root causes.
In a 2013 infinite cbd oil study, researchers treated mice with cbd and monitored their infinite cbd oil sleep factors.
Glaucoma is the 2nd leading cause of lost eyesight across the world, only trailing cataract.
A 2012 study infinite cbd oil showed infinite cbd oil that cbd exposure to rates helped suppress their appetite.
It is also the second infinite cbd oil most common of 104 infinite cbd oil cannabinoids found in cannabis plants, cbd oil in nebraska only second to thc which produces the feeling of high when you smoke or ingest marijuana.
I really want to hate someone and will ignore him for at least a year.
It infinite cbd oil s rare to be a confidant, but it s rare to be too far away. I don t know when to meet during this trip Every time I think of it, my heart feels sad.
At a glance, hesitated Cbd For Life Reviews investing in cbd oil to speak. Seeing her blocking the How To Use Cbd Oil For Pain infinite cbd oil door, Di Wu stood aside, his expression even infinite cbd oil more embarrassing.
The master was not invited to Adam Fields infinite cbd oil the scene, and the little thief escaped.
Later, I smelled the scent of julan, which was green and blue. Only then realized that the fruit is.
They want to wait for the shape to be born, swallow it. Eat enlightenment.
Lin Zheng is willing to help. Colorado Cures Cbd Oil infinite cbd oil .
Should cbd oil be taken with food?
Waiting for the next year, Qihou became more alert after being frightened, and the dragon s belly was more tightly protected.
Ye Pei hurriedly collected the demon light, grinned and said You talk to the puppy, I will listen, he is your lover.
As soon as he left the cave, he used a flying horse to take the two Cbd For Life Reviews investing in cbd oil to Qingmenxia and stopped midway.
Fang Xia was her first arrival, fearing her master. In infinite cbd oil case .
How long to wait before smoking after taking cbd oil?
of misunderstanding, I would resign early.
Due to the difficult situation, Fangxia must have self respect to avoid accidentally breaking the rules, exhausting others and harming herself, fearing the passion of Diwu as a teenager, and the flame of love burning unstoppable, and stopped him, and laughed in a low voice Okay.
Di Wu decided to beat the tiger to death with his hands. He caught sight of infinite cbd oil the little tiger running away, and hurriedly shouted Quickly chase , after a slight loss of God, the tiger suddenly wanted to roll away on the spot, with great power.
One female and three males recognized as the most powerful of the fourteen heroes.
It is helpless for a hundred days. It has to be hard to cultivate. It is afraid that liquid cannabis drops Diwu infinite cbd oil will be spoiled from childhood and can hardly endure hard work.
He didn t dare to neglect, and he hesitated when he heard the words. The poor man said angrily Don t you want Cbd For Life Reviews investing in cbd oil it grow your own hemp for cbd oil Di Wu hurriedly replied The younger generation dare not.
The enemy who appeared after seeing the demon was holding a black rod, How To Use Cbd Oil For Pain infinite cbd oil pulling Xiaohuazi, standing in the mist of the sea of needles, if nothing happened, there would be no treasure.
Immediately afterwards, a thin cyan oils for sleep apnea smoke flew from the poor man s hand, and the flying needle colored silk flying in the sky was swept away, shrunk into how much lotion do you put with cbd oil a big fist, and retracted.
After hiding in the investing in cbd oil Cbd Oil And Tooth Pain tree, don t leave me I caught a glimpse of a blue scaled python, about two or three feet long, holding a large bowl of python head, frequent red letters in the investing in cbd oil mouth, fierce light in the eyes, coming from the turf infinite cbd oil like a gallop, recognizing it was seen on the way last year That poisonous python, I saw it entrenched in the cliff, head up to the sky, just as a group of pheasants flew by, eating it open its mouth and How To Use Cbd Oil For Pain infinite cbd oil sucking, swallowing four or five in a row, the blood mouth moved slightly, all of them gutted, Hold your head up again With a squirt, the chicken feathers flying in the sky cbd oil false positive will spurt out.
Suddenly, the dragon rhinoceros disappeared suspiciously. This beast was psychic and loyal, and outsiders would not accept it.
The one splashed infinite cbd oil infinite cbd oil back hit the back of kansas cbd laws the hand and the joint. A few were interrupted, he threw the knife away, kept screaming, and stood aside vertically.
The infinite cbd oil enchantress took the opportunity to say to the audience that it Adam Fields infinite cbd oil is because infinite cbd oil the Wudao friends infinite cbd oil possess supernatural powers.
He was very anxious. infinite cbd oil cheapest price on green roads original nectar cbd oil Once the test was correct, he held the two maidservants under his side with one infinite cbd oil Facts About Cbd hand, and flew to Zhuyu Cliff together.
Hidden behind the cliff rock and prepared to deal with it, a man and two women came to the ground and were about to start the ambush.
She suddenly saw the demon light disappeared, and the silver rainbow played her work.
The Di Wu and his wife went first, Wen also self. Fly through the air.
Because I thought I was defeated, the enemy must go home. It won t be long without anyone infinite cbd oil infinite cbd oil coming, and I have been waiting here.
If infinite cbd oil you can worship the fairy master because of his strength, a classmate sword, fellow practitioners, it is wonderful, or you can ask him to introduce it to another fairy master, otherwise you will end up as a girl and no longer marry.
What s unique best hemp oil for pain about nuleaf naturals is that infinite cbd oil they mainly focus on one type of cbd oil.
Because of infinite cbd oil that, your doctor might recommend the following painkillersnonsteroidal anti inflammatory drugscounterirritantsdisease modifying antirheumatic drugscorticosteroidsbiologic response modifiers what s even worse about arthritis is that most treatments include infinite cbd oil a long list of side effects.
Com or by regular mail to the daily herald, letters, p.o.
Fangxia pursed her mouth at him, but she didn t pay attention, and opposed cbd oil drops carry on to switzerland from usa Yunluan s words The heart is strong and the stone is also worn.
It was expected to be good. I hurriedly told Di Wu to fly in together.
After pigs lost consciousness, he had carefully checked their bodies, tried their infinite cbd oil teeth and huge fangs with his fingers, and held the ferocious pig s face infinite cbd oil in his hands, looked at his drowsy eyes, listened to the respiratory tract, and was sure that there was no The question is to step on their tiny feet and infinite cbd oil tie them up, then pull up the canvas, send them into the infinite cbd oil Facts About Cbd pig cage, and close the sliding door tightly.
Flush the cargo area with steam. When I arrived at the Muskrat Farm, I encountered infinite cbd oil Facts About Cbd the last annoying thing.
At best, he would let a cannon that was about to collapse down, and he would investing in cbd oil Cbd Oil And Tooth Pain never threaten others again.
A picture of the Washington city squid .
What is the cbd oil at smoke shops made of?
appeared on the screen. The camera is pulled here, and the arrow is used to move around this area, understand Ok, nothing is captured on the lens.
She left him a few notes at the nursing station, writing as easy as possible on the letterhead with funny dog patterns.
My girlfriend made a dungeon like thing with me. He put his things in On the anvil, he took a fire stick and burned it in the stove.
From the bushes came a herd of hideous pigs, wolves, with long legs and thick chests, and a messy gray mane towering over them.
Dr. Lecter had a smell of fine black cloth. When he checked her pupils, she tried her best to keep her eyes open.
He focus d cbd oil might have heard giants fighting on the other side of the wall. He replaced the teapot with a silver belt buckle.
That s it. She said solemnly. The stairs creaked under her weight as she went downstairs. Barney locked the door and rested his head against the cool refrigerator for several minutes.
At the same time, the brain On the chupi layer, there are exchanges of etiquette, scenery, and banquets, just like the religious miracle paintings on the ceiling of a church illuminated by lights.
Now, while they are dancing on the big balcony, let s go quickly the clever Barney has left the city, and we must follow his example.
Jazz Pharmaceuticals Completes Acquisition of GW Pharmaceuticals plc
DUBLIN , May 5, 2021 /PRNewswire/ — Jazz Pharmaceuticals (Nasdaq: JAZZ) today announced the completion of its acquisition of GW Pharmaceuticals plc (Nasdaq: GWPH) (“GW”), a leader in the science, development and commercialization of cannabinoid-based prescription medicines.
“We are excited to welcome our GW colleagues to Jazz as we mark a transformative milestone in creating an innovative, high-growth, global biopharma leader in neuroscience with a worldwide commercial and operational footprint,” said Bruce Cozadd , chairman and chief executive officer of Jazz Pharmaceuticals. “The addition of GW further diversifies our commerical portfolio and innovative pipeline with therapies that are complementary to our existing business, including Epidiolex, a high-growth commercial product with near-term blockbuster potential. We are fortunate to be combining two companies that share a passion for, and track record of, developing differentiated therapies that advance science and the care of patients with often-overlooked diseases. We look forward to building an even stronger company together and are excited about the greater impact we will continue to drive for patients, customers and shareholders.”
Compelling Strategic Rationale
- Adds third high-growth commercial franchise: Epidiolex ® (cannabidiol) oral solution is a transformative treatment for childhood-onset epilepsy that provides a critical therapeutic option for refractory seizures. Launched in the U.S. in 2018, Epidiolex exceeded $500 million in annual net sales in 2020. With a recent launch in Europe (under the tradename Epidyolex ® ) and ongoing research in additional indications, the Company believes Epidiolex has near-term blockbuster potential.
- Diversifies pipeline to drive sustainable growth: The Company’s robust pipeline now includes clinical-stage development programs addressing significant unmet patient needs across neuroscience and oncology, including in sleep, movement disorders, psychiatry, hematology and solid tumors.
- Shared culture and exceptional talent advances our goal to support patients: The global teams at Jazz and GW possess unique talents and expertise, as well as a shared commitment to, and proven success in, delivering differentiated therapies to support people with serious, often-overlooked diseases. GW, like Jazz, has a demonstrated history of honoring values that include integrity, collaboration, passion, innovation and the pursuit of excellence, and a culture where diversity, equity, inclusion and belonging are a priority.
- Expected to deliver substantial shareholder value: This transaction is expected to provide accelerated double-digit top-line revenue growth and to be accretive in the first full calendar year of combined operations, and substantially accretive thereafter. Jazz’s strong cash flow profile provides the capability to rapidly deleverage to a target net leverage of less than 3.5x by the end of 2022.
- Chris Tovey , chief operating officer (COO) of GW since 2012, will join Jazz’s executive management as executive vice president, chief operating officer, and managing director Europe & International, reporting to Dan Swisher , president. Mr. Tovey brings over 30 years of commercial and operations experience in the pharmaceutical industry and deep knowledge of GW’s growing global cannabinoid business. In his role, Mr. Tovey will be responsible for commercialization activities outside North America , manufacturing and supply chain, and information systems and security.
- The Company plans to provide 2021 financial guidance for the combined Jazz/GW organization within the next 45 days.
- Under the terms of the agreement, holders of GW ADSs, which each represented 12 GW ordinary shares, will be entitled to receive $220.00 for each GW ADS, consisting of $200.00 in cash and $20.00 in Jazz ordinary shares. The number of Jazz ordinary shares received per GW ADS is 0.12036, based on the volume weighted average price of Jazz ordinary shares on Nasdaq for the 15 consecutive trading day period beginning on the 18 th trading day immediately preceding the closing date of the transaction. Holders of GW ordinary shares that are not in ADS form will be entitled to receive the foregoing consideration divided by 12 per GW ordinary share.
About Jazz Pharmaceuticals plc
Jazz Pharmaceuticals plc (NASDAQ: JAZZ) is a global biopharmaceutical company whose purpose is to innovate to transform the lives of patients and their families. We are dedicated to developing life-changing medicines for people with serious diseases – often with limited or no therapeutic options. We have a diverse portfolio of marketed medicines and novel product candidates, from early- to late-stage development, in neuroscience and oncology. We actively explore new options for patients including novel compounds, small molecules and biologics, and through cannabinoid science and innovative delivery technologies. Jazz is headquartered in Dublin, Ireland and has employees around the globe, serving patients in nearly 75 countries. For more information, please visit www.jazzpharmaceuticals.com and follow @JazzPharma on Twitter.
Caution Concerning Forward Looking Statements
This press release contains forward-looking statements, including, but not limited to, statements related to Jazz Pharmaceuticals’ growth prospects and future financial and operating results, including statements related to the acquisition of GW Pharmaceuticals and the anticipated results and benefits thereof, including the sales prospects for Epidiolex, double-digit increases in top line revenue growth and expectations about the accretive impact of the acquisition; the company’s expected cash flow supporting the company’s rapid de-leveraging and positioning the company to meet its stated leverage targets; and other statements that are not historical facts. These forward-looking statements are based on the company’s current plans, objectives, estimates, expectations and intentions and inherently involve significant risks and uncertainties.
Actual results and the timing of events could differ materially from those anticipated in such forward- looking statements as a result of these risks and uncertainties, which include, without limitation, risks and uncertainties associated with: risks related to diverting the attention of GW Pharmaceuticals and Jazz Pharmaceuticals management from ongoing business operations; failure to realize the expected benefits of the acquisition; significant transaction costs and/or unknown or inestimable liabilities; the risk that GW Pharmaceuticals’ business will not be integrated successfully or that such integration may be more difficult, time-consuming or costly than expected; risks related to future opportunities and plans for the combined company, including the uncertainty of expected future regulatory filings, financial performance and results of the combined company following completion of the acquisition; GW Pharmaceuticals’ dependence on the successful commercialization of Epidiolex/Epidyolex and the uncertain market potential of Epidiolex; pharmaceutical product development and the uncertainty of clinical success; the regulatory approval process, including the risks that GW Pharmaceuticals may be unable to submit anticipated regulatory filings on the timeframe anticipated, or at all, or that GW Pharmaceuticals may be unable to obtain regulatory approvals of any of its product candidates, including nabiximols and Epidiolex for additional indications, in a timely manner or at all; disruption from the acquisition of GW Pharmaceuticals, making it more difficult to conduct business as usual or maintain relationships with customers, employees or suppliers; effects relating to the consummation of the acquisition on the market price of Jazz Pharmaceuticals’ ordinary shares; the possibility that, if Jazz Pharmaceuticals does not achieve the perceived benefits of the acquisition as rapidly or to the extent anticipated by financial analysts or investors, the market price of Jazz Pharmaceuticals’ ordinary shares could decline; regulatory initiatives and changes in tax laws; market volatility; the ultimate duration and severity of the COVID-19 pandemic and resulting global economic, financial, and healthcare system disruptions and the current and potential future negative impacts to the company’s business operations and financial results; maintaining or increasing sales of and revenue from the company’s oxybate products and other key marketed products; effectively launching and commercializing the company’s other products and product candidates; the time-consuming and uncertain regulatory approval process, including the risk that the company’s planned regulatory submissions may not be submitted, accepted or approved by applicable regulatory authorities in a timely manner or at all; the costly and time-consuming pharmaceutical product development process and the uncertainty of clinical success, including risks related to failure or delays in successfully initiating or completing clinical trials and assessing patients such as those being experienced, and expected to continue to be experienced, by the company as a result of the effects of the COVID-19 pandemic; protecting and enhancing the company’s intellectual property rights; delays or problems in the supply or manufacture of the company’s products and product candidates; complying with applicable U.S. and non-U.S. regulatory requirements; government investigations, legal proceedings and other actions; obtaining and maintaining adequate coverage and reimbursement for the company’s products; identifying and acquiring, in-licensing or developing additional products or product candidates, financing these transactions and successfully integrating acquired product candidates, products and businesses; the company’s ability to realize the anticipated benefits of its collaborations and license agreements with third parties; the company’s ability to achieve expected future financial performance and results and the uncertainty of future tax and other provisions and estimates; and other risks and uncertainties affecting the company and GW Pharmaceuticals, including those described from time to time under the caption “Risk Factors” and elsewhere in Jazz Pharmaceuticals’ and GW Pharmaceuticals’ Securities and Exchange Commission filings and reports, including the company’s Form 10-K for the year ended December 31, 2020 , GW Pharmaceuticals’ Form 10-K for the year ended December 31, 2020 and future filings and reports by either company. In addition, while the company expects the COVID-19 pandemic to continue to adversely affect its business operations and financial results, the extent of the impact on the company’s ability to generate sales of and revenues from its approved products, execute on new product launches, its clinical development and regulatory efforts, its corporate development objectives and the value of and market for its ordinary shares, will depend on future developments that are highly uncertain and cannot be predicted with confidence at this time, such as the ultimate duration and severity of the pandemic, governmental “stay-at-home” orders and travel restrictions, quarantines, social distancing and business closure requirements in the U.S., Ireland and other countries, and the effectiveness of actions taken globally to contain and treat the disease. Moreover, other risks and uncertainties of which the company is not currently aware may also affect the company’s forward-looking statements and may cause actual results and the timing of events to differ materially from those anticipated.
Andrea N. Flynn , Ph.D.
Vice President, Head, Investor Relations
Jazz Pharmaceuticals plc
Ireland +353 1 634 3211
Vice President, Corporate Affairs & Government Relations
Jazz Pharmaceuticals plc
Ireland , +353 1 697 2141
U.S. +1 215 867 4910
Cannabis-based medicines–GW pharmaceuticals: high CBD, high THC, medicinal cannabis–GW pharmaceuticals, THC:CBD
GW Pharmaceuticals is undertaking a major research programme in the UK to develop and market distinct cannabis-based prescription medicines [THC:CBD, High THC, High CBD] in a range of medical conditions. The cannabis for this programme is grown in a secret location in the UK. It is expected that the product will be marketed in the US in late 2003. GW’s cannabis-based products include selected phytocannabinoids from cannabis plants, including D9 tetrahydrocannabinol (THC) and cannabidiol (CBD). The company is investigating their use in three delivery systems, including sublingual spray, sublingual tablet and inhaled (but not smoked) dosage forms. The technology is protected by patent applications. Four different formulations are currently being investigated, including High THC, THC:CBD (narrow ratio), THC:CBD (broad ratio) and High CBD. GW is also developing a specialist security technology that will be incorporated in all its drug delivery systems. This technology allows for the recording and remote monitoring of patient usage to prevent any potential abuse of its cannabis-based medicines. GW plans to enter into agreements with other companies following phase III development, to secure the best commercialisation terms for its cannabis-based medicines. In June 2003, GW announced that exclusive commercialisation rights for the drug in the UK had been licensed to Bayer AG. The drug will be marketed under the Sativex brand name. This agreement also provides Bayer with an option to expand their license to include the European Union and certain world markets. GW was granted a clinical trial exemption certificate by the Medicines Control Agency to conduct clinical studies with cannabis-based medicines in the UK. The exemption includes investigations in the relief of pain of neurological origin and defects of neurological function in the following indications: multiple sclerosis (MS), spinal cord injury, peripheral nerve injury, central nervous system damage, neuroinvasive cancer, dystonias, cerebral vascular accident and spina bifida, as well as for the relief of pain and inflammation in rheumatoid arthritis and also pain relief in brachial plexus injury. The UK Government stated that it would be willing to amend the Misuse of Drugs Act 1971 to permit the introduction of a cannabis-based medicine. GW stated in its 2002 Annual Report that it was currently conducting five phase III trials of its cannabis derivatives, including a double-blind, placebo-controlled trial with a sublingual spray containing High THC in more than 100 patients with cancer pain in the UK. Also included is a phase III trial of THC:CBD (narrow ratio) being conducted in patients with severe pain due to brachial plexus injury, as are two more phase III trials of THC:CBD (narrow ratio) targeting spasticity and bladder dysfunction in multiple sclerosis patients. Another phase III trial of THC:CBD (narrow ratio) in patients with spinal cord injury is also being conducted. Results from the trials are expected during 2003. Three additional trials are also in the early stages of planning. These trials include a phase I trial of THC:CBD (broad ratio) in patients with inflammatory bowel disease, a phase I trial of High CBD in patients with psychotic disorders such as schizophrenia, and a preclinical trial of High CBD in various CNS disorders (including epilepsy, stroke and head injury). GW Pharmaceuticals submitted an application for approval of cannabis-based medicines to UK regulatory authorities in March 2003. Originally GW hoped to market cannabis-based prescription medicines by 2004, but is now planning for a launch in the UK towards the end of 2003. Several trials for GW’s cannabis derivatives have also been completed, including four randomised, double-blind, placebo-controlled phase III clinical trials conducted in the UK. The trials were initiated by GW in April 2002, to investigate the use of a sublingual spray containing THC:CBD (narrow ratio) in the following medical conditions: pain in spinal cord injury, pain and sleep in MS and spinal cord injury, neuropathic pain in MS and general neuropathic pain (presented as allodynia). Results from these trials show that THC:CBD (narrow ratio) caused statistically significant reductions in neuropathic pain in patients with MS and other conditions. In addition, improvements in other MS symptoms were observed as well. Phase II studies of THC:CBD (narrow ratio) have also been completed in patients with MS, spinal cord injury, neuropathic pain and a small number of patients with peripheral neuropathy secondary to diabetes mellitus or AIDS. A phase II trial of THC:CBD (broad ratio) has also been completed in a small number of patients with rheumatoid arthritis, as has a trial of High CBD in patients with neurogenic symptoms. A phase II trial has also been evaluated with High THC in small numbers of patients for the treatment of perioperative pain. The phase II trials provided positive results and confirmed an excellent safety profile for cannabis-based medicines. GW Pharmaceuticals received an IND approval to commence phase II clinical trials in Canada in patients with chronic pain, multiple sclerosis and spinal cord injury in 2002. Following meetings with the US FDA, Drug Enforcement Agency (DEA), the Office for National Drug Control Policy, and National Institute for Drug Abuse, GW was granted an import license from the DEA and has imported its first cannabis extracts into the US. Preclinical research with these extracts in the US is ongoing.
Rog DJ, Nurmikko TJ, Young CA. Rog DJ, et al. Clin Ther. 2007 Sep;29(9):2068-79. doi: 10.1016/j.clinthera.2007.09.013. Clin Ther. 2007. PMID: 18035205 Clinical Trial.
[No authors listed] [No authors listed] Drugs R D. 2007;8(2):103-12. doi: 10.2165/00126839-200708020-00005. Drugs R D. 2007. PMID: 17324008 Review.
Langford RM, Mares J, Novotna A, Vachova M, Novakova I, Notcutt W, Ratcliffe S. Langford RM, et al. J Neurol. 2013 Apr;260(4):984-97. doi: 10.1007/s00415-012-6739-4. Epub 2012 Nov 21. J Neurol. 2013. PMID: 23180178 Clinical Trial.
[No authors listed] [No authors listed] Drugs R D. 2007;8(3):176-87. doi: 10.2165/00126839-200708030-00005. Drugs R D. 2007. PMID: 17472413 Review.
[No authors listed] [No authors listed] Drugs R D. 2004;5(6):339-42. doi: 10.2165/00126839-200405060-00005. Drugs R D. 2004. PMID: 15563237 Review.
Navarrete C, García-Martín A, Rolland A, DeMesa J, Muñoz E. Navarrete C, et al. Int J Mol Sci. 2021 Mar 15;22(6):2992. doi: 10.3390/ijms22062992. Int J Mol Sci. 2021. PMID: 33804243 Free PMC article. Review.
Brunetti P, Pichini S, Pacifici R, Busardò FP, Del Rio A. Brunetti P, et al. Medicina (Kaunas). 2020 May 15;56(5):237. doi: 10.3390/medicina56050237. Medicina (Kaunas). 2020. PMID: 32429074 Free PMC article. Review.
Al-Ghezi ZZ, Miranda K, Nagarkatti M, Nagarkatti PS. Al-Ghezi ZZ, et al. Front Immunol. 2019 Aug 21;10:1921. doi: 10.3389/fimmu.2019.01921. eCollection 2019. Front Immunol. 2019. PMID: 31497013 Free PMC article.
Kim A, Kaufmann CN, Ko R, Li Z, Han BH. Kim A, et al. J Palliat Med. 2019 Oct;22(10):1196-1201. doi: 10.1089/jpm.2018.0529. Epub 2019 Mar 25. J Palliat Med. 2019. PMID: 30909786 Free PMC article.
Cone EJ, Bigelow GE, Herrmann ES, Mitchell JM, LoDico C, Flegel R, Vandrey R. Cone EJ, et al. J Anal Toxicol. 2015 Sep;39(7):497-509. doi: 10.1093/jat/bkv070. Epub 2015 Jul 2. J Anal Toxicol. 2015. PMID: 26139312 Free PMC article.