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Multiple sclerosis is a complex disorder, and researchers cannot pinpoint an exact cause. However, the effects of cannabis and CBD could be valuable to patients seeking relief from various symptoms.

The U.S. National Library of Medicine acknowledges cannabidiol (CBD) as having the potential to relieve “spasticity in adult patients with multiple sclerosis (MS).” However, due to the condition’s varying nature and random flare-ups, MS is still a frustrating disease to treat. Indeed, multiple sclerosis affects no two people in the same way.

Although dozens of prescription medications are available, conventional drugs vary in efficacy. This is largely why the topic of CBD oil for multiple sclerosis is advancing into the limelight.

This article will discuss how MS attacks nerve fibers and disrupts neurological pathways. It also discusses how cannabidiol (CBD) can influence these pathways. While one should not consider CBD oil for multiple sclerosis a cure, it may provide an alternative form of relief.

DID YOU KNOW? Multiple sclerosis is a rare disease that only affects about 1 in 275 American adults.

What Is Multiple Sclerosis?

The National Multiple Sclerosis Society defines MS as an “immune-mediated” condition. The body’s immune system attacks the central nervous system (which comprises the brain and spinal cord).

After nerve fiber damage, scar tissue begins to form. This scar tissue can interrupt neurological communication between the brain and other body parts. Neural communication is vital for many functions in humans, including motor skills and behavior.

The severity of symptoms that people living with multiple sclerosis experience depends on the location of nerve fiber damage. It also depends on how many fibers are damaged. In milder cases, MS symptoms can be as moderate as mood swings or muscle spasms. In more severe cases, sufferers may have paralysis and/or a complete inability to control bodily functions.

As for prevalence, multiple sclerosis is a relatively rare disease. The National Multiple Sclerosis Society says that approximately 900,000 Americans live with the condition. Research suggests that up to 2.8 million people have the condition worldwide.

While researchers are in the dark about what triggers MS, we know some things about it. For instance, we know that women of northern European descent between the ages of 20 and 55 are most at risk.

MS Risk Factors

Genetics and family history play an important part in the onset of MS. We also know that exposure to environmental agents can increase risk. The good news is that not all sufferers experience overly-debilitating symptoms. Many maintain relatively normal day-to-day lives.

Also, contrary to popular belief, multiple sclerosis is not necessarily a terminal disease. In some instances, the disease is degenerative (meaning it worsens over time) and ends in death. However, the average lifespan of individuals with multiple sclerosis is marginally shorter than the average US adult lifespan.

Conventional (Non-Cannabis) MS Treatment Methods

Multiple sclerosis exists in four different stages, or “disease courses.” Conventional treatments and prescriptions depend on which particular stage a patient is in. In order of increasing severity, the four courses of MS are:

  1. Clinically Isolated Syndrome (CIS)
  2. Relapsing-Remitting MS (RRMS)
  3. Primary-Progressive MS (PPMS)
  4. Secondary-Progressive MS (SPMS).

Given multiple sclerosis’s “come and go” nature, patients can go months or even years without a diagnosis. However, in the event of diagnosis, prescription meds are typically the treatment of choice. Prescription MS medications include interferons like Avonex and Betaseron and immunomodulators like Copaxone.

Interferons work by lowering the number of white blood cells in the body. This limits the sources of attack on CNS nerve fibers. However, since white blood cells make up the immune system and protect against disease, these drugs can be dangerous. They can even produce side effects similar to those of chemotherapy.

MS Drugs – Side Effects

Immunomodulators like Copaxone generally present fewer severe side effects than interferons. However, these drugs are not always effective for patients. Functionally, they act as “sacrificial myelin” during MS flare-ups. This is when synthetically-produced amino acids take the brunt of the immune response rather than the myelin protective coatings of the nerve fibers themselves.

Ultimately, most MS sufferers are generally unconcerned about the kind of treatment they take or where it comes from. The only thing that matters to them is whether or not the medication is effective and to what extent it allows them to live a normal life. Those who seek alternatives like CBD oil generally do so for one of the following reasons:

  • Their prescription meds are ineffective
  • Their prescribed medical regimen results in severe or regular side effects
  • Prescription medications are too expensive

Important Information on CBD & Multiple Sclerosis

One thing we didn’t necessarily clarify is the difference in function between CBD and THC. THC, of course, is the archetypal marijuana component. It’s what’s responsible for getting us high and has been the driving force behind generations of legal condemnation and “lazy stoner” typecasts.

On the other hand, CBD has none of these intoxicating properties. It won’t cause a high any more than an ibuprofen tablet will. Rather, the molecule functions as an “endocannabinoid supplement.”

Our bodies are filled with natural cannabinoid receptors that work with natural endocannabinoids. If there is an absence or deficiency in producing these endocannabinoids, the receptors can’t function properly.

The central nervous system is the body region most densely populated with cannabinoid receptors – the same region where multiple sclerosis attacks nerve fibers.

MS and a Possible Endocannabinoid Deficiency

Could multiple sclerosis potentially be a disease hinged on a basic endocannabinoid deficiency? No one can answer that question without years of research. That said, anecdotal evidence suggests an uncanny relationship between the two components.

More research is needed to understand any potential dynamic between MS and endocannabinoid deficiency.

For the time being, at least, it seems that people living with multiple sclerosis will continue to rely on self-treatment methods. Unless they live in a state with MMJ, they will have to resort to non-conventional approaches to obtain alternative medications like CBD oil.

Cannabis & CBD Oil Benefits for MS – What Does the Research Say?

Believe it or not, dozens of academic and research publications have been released in recent years concerning the use of cannabinoids as a potential MS treatment. Here, we point out five of the most relevant studies to date.

PUBLICATION

“There is a wide acceptance of cannabis [use] within the MS community: up to 60% of PwMS victims currently use cannabis, and up to 90% would consider using it if it were legal and more scientific evidence was available.”

Sativex is a cannabis-based, FDA-approved medication for the “adjunctive treatment of neuropathic pain in patients with multiple sclerosis (MS).”

“CBD provides long-lasting protection against the effects of inflammation in a viral model of multiple sclerosis.”

“…nearly every participant in a 1997 survey of 112 regular marijuana users with multiple sclerosis [stated] that the drug lessened both pain and spasticity.”

A review of studies from 1970 to 2013 looked into the potential benefits of complementary and alternative medicine in MS. The researchers suggested that “clinicians might offer oral cannabis extract for spasticity symptoms and pain.”

CBD Treatment for MS: Are There Any Side Effects?

CBD is generally recognized as being safe for consumption. Unlike THC, it is non-intoxicating, and there is little risk of developing an addiction.

Nonetheless, there are some potential side effects to watch out for, including:

  • Fatigue
  • Drowsiness
  • Diarrhea
  • Dry mouth
  • Lightheadedness
  • Crankiness
  • Reduced appetite

CBD is not FDA-approved, and the marketplace is poorly regulated. Therefore, one of the biggest risks is purchasing a low-grade product containing contaminants. It is important only to buy products with third-party lab reports outlining what’s inside.

Also, CBD can interact with certain medications. Therefore, any MS patients currently using prescription or over-the-counter drugs should consult with a physician before using CBD.

How to Take CBD Oil for MS

There is a wide variety of CBD products available. Here are the most common, along with information on how to consume them:

  • CBD Oil: Place a few drops beneath the tongue, and hold them there for 60-90 seconds before swallowing.
  • CBD Topicals: Rub the topical onto the affected area.
  • CBD Vape Juice: It is possible to buy disposable vaporizers with pre-filled CBD juice cartridges. Alternatively, one can add the liquid to the vape device’s tank. The vaporizer heats the liquid, creating a vapor that the user inhales.
  • CBD Edibles: The most common options include gummies and chocolate. Using edibles is as easy as chewing and swallowing!
  • CBD Capsules: Swallow these capsules with some water. They are ideal for anyone who doesn’t like the taste or texture of CBD oil.
  • CBD Flower: This is smokable dried hemp flower.

Typically, smoking and vaping provide the most rapid effects, but there are health concerns with both. CBD oil is the most popular and takes effect relatively quickly. CBD edibles and capsules are easy to use but can take a while to have a noticeable impact. Finally, CBD topicals are useful for anyone looking to tackle pain in a specific body area.

Final Thoughts on CBD Oil for Multiple Sclerosis

The research above indicates that CBD has potential promise for people living with multiple sclerosis. It is less expensive than pharmaceutical drugs, has fewer side effects, and could help alleviate many MS symptoms. However, detailed clinical trials involving humans are necessary to learn more about CBD for MS, including safety, efficacy, dosage, and more.

Nonetheless, many MS patients are unwilling to wait and want to try CBD as soon as possible. Fortunately, CBD products are tolerated in most states as long as they come from hemp and have a maximum THC content of 0.3%. Below, we have included details of what we believe are among the best CBD brands in the industry.

A note on CBD for Multiple Sclerosis by Dr. Mosab Deen:

“In essence, it is vital to understand that CBD may not only relieve symptoms of multiple sclerosis, without inflated pharmaceutical prices or their unhealthy side effects but may be the secret cure to preventive neurodegeneration through the endocannabinoid pathway that MS patients suffer from.”

CBD for MS (Multiple Sclerosis) – August 2022

According to The National Multiple Sclerosis Society, approximately 85% of people with MS are initially diagnosed with relapsing-remitting MS (RRMS) (5 ) .

RRMS is a type of MS characterized by inflammatory attacks on the nerve fibers and myelin, the layers of insulating membranes surrounding nerve fibers in the central nervous system (CNS).

While RRMS is defined by attacks or relapses of new MS symptoms, progressive forms of MS involve fewer attacks.

The progressive types of MS are secondary-progressive MS (SPMS), primary-progressive MS (PPMS), and progressive-relapsing MS (PRMS).

The symptoms of MS vary, but they often include pain, inflammation, muscle spasticity, MS fatigue, and depression.

Spasticity is a condition characterized by an abnormal increase in muscle tone or stiffness of muscle, which might interfere with movement.

MS symptoms can reduce physical activity, negatively impact functional mobility, and have a detrimental effect on a person’s quality of life (6) .

Although there have been recent significant advances in disease-modifying therapy, none of the current treatments stops or cures MS-related symptoms (7 ) .

Thus, many people with MS look for alternative and complementary therapies, such as cannabis plants and their derivatives.

CBD for Multiple Sclerosis: What The Research Says

Sativex is a cannabis-based prescription medicine that contains a 1:1 CBD (cannabidiol)-THC (delta-9-tetrahydrocannabinol) ratio.

Approved as an additional treatment for nerve pain and spasticity in multiple sclerosis patients, Sativex is administered as a mouth spray (oromucosal) (8 ) .

In a 2005 study published in Issues in Emerging Health Technologies , 368 patients with various neurological conditions, including MS, were given the THC:CBD spray (9 ) .

Results showed that the spray significantly reduced nerve pain, spasticity, muscle spasms, and sleep disturbances among the human subjects.

However, the researchers observed adverse events, like dizziness, sleepiness, fatigue, feeling of intoxication, and experiencing an unpleasant taste.

A 2016 study in Therapeutic Advances in Neurological Disorders summarized the evidence for the efficacy and effectiveness of THC-CBD oromucosal spray in symptom management for those experiencing spasticity due to MS (10 ) .

Researchers believe that for individuals with resistant moderate to severe MS-induced spasticity, THC-CBD spray can be a treatment option.

It was only in 2017 when a pre-clinical study on CBD alone was conducted. The study, published in CNS and Neurological Disorders – Drug Targets, showed that CBD could produce beneficial effects in individuals with MS (11 ) .

How CBD Oil Works to Help With Multiple Sclerosis

The two primary cannabinoid receptors are CB1 and CB2. CB1 receptors are found in the CNS (the brain and spinal cord), intestines, connective tissues, and other glands.

CB2 receptors are mostly located in the spleen, tonsils, and immune cells. Only a few are in the brain.

Data suggests that CBD does bind to the receptors but does not directly activate them. Instead, it appears to adjust how the receptors respond to stimulation from other compounds, such as THC (12 ) .

The authors of a study, published in the British Journal of Pharmacology in 2010, noted there had been anecdotal and scientific evidence of cannabis providing symptomatic relief in neurodegenerative disorders, including MS (13 ) .

The study results implied that the endocannabinoid system (ECS) impairment might be responsible for some disease symptoms.

The ECS plays an active role in regulating a wide range of body functions, including pain sensation, immune response, anxiety , mood, appetite, sleep, metabolism, and memory.

The CBD-THC spray, Sativex, acts via cannabinoid receptors distributed throughout the CNS and in immune cells (14 ) .

CB2 is involved in weakening inflammatory immune cell response to disease.

Meanwhile, the activation of CB1 receptors has been shown to block the release of glutamate, a chemical transmitter released by nerve cells in the brain (15 ) .

See also  CBD Oil For Leukemia

Abnormal or excessive glutamate levels and signaling in the nervous system can contribute to MS (16 ) .

The Pros and Cons of CBD Oil for Multiple Sclerosis

Pros
  • Evidence suggests that CBD may reduce MS symptoms, such as MS fatigue, pain, and spasticity, and ultimately improve mobility (17 ) .
  • The 2018 Farm Bill has legalized CBD products derived from hemp. However, individual states in the United States have their legislation (18 ) .
  • The American Academy of Neurology has highlighted the safety profile and benefits of cannabis in a review of medical marijuana (medical cannabis).

The review was conducted to address the treatment of symptoms of MS, epilepsy, and movement disorders (19 ) .

  • No studies have investigated the effects of cannabis oil on mobility in individuals with MS. However, some studies have suggested that CBD may exert positive effects on health by reducing inflammation and relieving pain (20 ) .
Cons
  • Studies are too limited to determine if CBD is an effective treatment for conditions other than those approved by the US Food and Drug Administration (FDA).
  • There are risks in using CBD. Possible side effects include dry mouth, drowsiness, diarrhea, fatigue, and reduced appetite (21 ) .
  • CBD can interact with other drugs and alter how the body metabolizes certain medications, as a 2017 research noted (22 ) .
    • A 2017 review revealed labeling inaccuracies in some CBD products. Some products had less CBD than stated in the label, while others had more (23 ) .

    How CBD Oil Compares to Alternative Treatments for Multiple Sclerosis

    Some of the alternative or complementary therapy options for MS include massage and a healthy, well-balanced diet with linoleic acid supplementation (24 ) .

    Regular massage therapy can help MS patients relax and reduce stress and depression, which can exacerbate the disease.

    CBD oil tinctures can be combined with massage oils. Like massage oils, CBD-infused bath bombs can help provide relaxation and relief from physical tension and emotional stress.

    A study published in the journal CNS and Neurological Disorders – Drug Targets noted that CBD had therapeutic uses as an anti-anxiety-like and an antidepressant-like compound (25 ) .

    There is also evidence that taking an oral supplement of linoleic acid (found in evening primrose oil) may improve MS symptoms.

    Researchers of a 2019 study found that higher levels of α-linolenic acid (ALA) were associated with lower disease activity in MS patients (26 ) .

    Meanwhile, cannabis extracts from Sativa cultivars (Cannabaceae) are rich in linoleic acid (57.1%), according to researchers of a 2012 study published in the European Journal of Lipid Science and Technology (27 ) .

    How to Choose the Right CBD

    Consider the following to ensure the reliability and safety of the CBD products purchased.

        1. Research on the legal stipulations applicable to CBD in the area where it would be bought and used.
        2. Read product reviews before buying from an online store. Check if the store is authorized by the government to sell CBD.
        3. Look for the certificate of analysis (COA) of the CBD product. A COA is a laboratory report that includes cannabinoid content and other tested compounds.
        4. Compare company claims with that of third-party lab testing reports.

      CBD Dosage for Multiple Sclerosis

      The appropriate dose of cannabinoids for specific medical conditions is not known . However, there are suggested doses for some multiple sclerosis symptoms, like pain and spasticity.

      A 2011 systematic review that examined the effects of cannabinoids of any type (smoked cannabis, oral extracts, nabilone, synthetic THC, nabiximols) showed that cannabinoids provided pain relief (28 ) .

      When using Sativex for the first time for MS-related pain and spasticity, follow the number of sprays on the days and times in the table below as reference (29 ) .

      Each 100 microlitre spray contains 2.7 mg THC and 2.5 mg CBD.

      (Between waking up and noon)

      (Between 4 pm and bedtime)

      A 2011 study noted that high doses of 1,500 mg CBD a day is well-tolerated by humans (30 ) . Still, always consult with a doctor before taking any CBD products.

      How to Take CBD Oil for Multiple Sclerosis

      A topical CBD cream or patch is ideal to use for inflammation or pain in a specific area. The CBD can target localized clusters of cannabinoid receptors, rather than interacting with the entire endocannabinoid system (ECS).

      CBD oil capsules and edibles, such as gummies , brownies, and lozenges, are a convenient and straightforward way to take CBD oil, especially for beginners.

      Meanwhile, CBD oil tinctures and sprays may be practical options for those who seek fast results and maximum dosage control.

      Conclusion

      CBD alone or its combination with another cannabinoid, like THC, may help alleviate many common MS symptoms.

      Unfortunately, studies on the use of CBD for specific medical conditions in humans are limited, and CBD’s long-term effects remain unknown.

      More longitudinal research is required to gather more scientific evidence and validate results from previous studies.

      Consulting with a doctor experienced in CBD use is ideal before using CBD or any cannabis products.

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